The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease.

نویسندگان

  • P G Kehoe
  • H Williams
  • P Holmans
  • G Wilcock
  • N J Cairns
  • J Neal
  • M J Owen
چکیده

Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the epsilon4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p=0.75) or alleles (p=0.70) between patients and controls. Moreover, despite a significant excess of ApoE epsilon4 in patients versus controls (p<0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (chi2=1.49, df=4, p=0.83).

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Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease.

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عنوان ژورنال:
  • Journal of medical genetics

دوره 35 12  شماره 

صفحات  -

تاریخ انتشار 1998